Download A calcium-based phantom bursting model for pancreatic islets by Richard Bertram, Arthur Sherman PDF

By Richard Bertram, Arthur Sherman

Insulin-secreting β-cells, positioned in the pancreatic islets of Langerhans, are excitable cells that produce usual bursts of motion potentials while inspired by way of glucose. the program has been the point of interest of mathematical research for 2 many years, spawning an array of mathematical types. lately, a brand new category of versions has been brought known as 'phantom bursters' [Bertram et al. (2000) Biophys. J. seventy nine, 2880-2892], which bills for the big variety of burst frequencies exhibited via islets through the interplay of multiple sluggish technique. right here, we describe one implementation of the phantom bursting mechanism during which intracellular Ca2+ controls the oscillations via either direct and oblique detrimental suggestions pathways. We express how the version dynamics should be understood via an extension of the fast/slow research that's quite often hired for bursting oscillations. From this attitude, the version uses a number of levels of freedom to generate the entire diversity of bursting oscillations exhibited by means of β-cells. The version additionally bills for quite a lot of experimental phenomena, together with the ever present triphasic reaction to the step elevation of glucose and responses to perturbations of inner Ca2+ shops. even though it isn't shortly an entire version of all β-cell houses, it demonstrates the layout rules that we expect will underlie destiny development in β-cell modeling.

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